李婷     博士/特聘副研究员/硕导

       电话/传真：021-64251287

              E-mail:  tingli@ecust.edu.cn

      通讯地址：上海市徐汇区梅陇路130号实验十八楼733；邮编：200237

个人简介

2018年9月毕业于环球360游戏，获生物化学与分子生物学专业的博士学位，随后进入华东理工大学药学专业从事博士后研究工作。2022年7月出站留校工作，被聘为特聘副研究员，在赵玉政教授团队从事教学科研工作。

聚焦细胞代谢监控技术开发与生物医药研究，通过细胞药物治疗、高通量代谢药物筛选、在体可视化追踪、药物靶点研究及临床疾病危险标志物发现等方式揭示生命过程的化学本质，解析疾病发生发展机制，促进生物医药的发展。主要研究成果发表在Cell Metabolism、Nature Communications、Nature Protocols、Nucleic Acids Research等国内外知名学术期刊。入选2019年上海市青年科技英才扬帆计划，同年获得国家自然科学基金青年科学基金项目和中国博士后科学基金面上项目。

研究方向

1. 基于光遗传学的细胞控制技术的开发与应用

2. 细胞代谢监测成像新技术的开发与应用

    

代表性论文

1. Rui Li^#, Yan Li^#, Kun Jiang^#, Lijuan Zhang^#, Ting Li^#, Aihua Zhao#, Zhuo Zhang, Yale Xia, Kun Ge, Yaqiong Chen, Chengnuo Wang, Weitao Tang, Shuning Liu, Xiaoxi Lin, Yuqin Song, Jie Mei, Chun Xiao, Aoxue Wang, Yejun Zou, Xie Li, Xianjun Chen, Zhenyu Ju, Wei Jia, Joseph Loscalzo8, Yu Sun, Wei Fang*, Yi Yang*, Yuzheng Zhao*. Lighting up arginine metabolism reveals its functional diversity in physiology and pathology, Cell Metabolism, 2024, in press.

2. Aoxue Wang^#, Yejun Zou^#, Shuning Liu^#, Xiuze Zhang^#, Ting Li*, Lijuan Zhang, Ruwen Wang, Yale Xia, Xie Li, Zhuo Zhang, Tiemin Liu, Zhenyu Ju, Ru Wang*, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors, Nature Protocols, 2024, 19(5), 1311–1347.

3. Fei Pan^#, Cheng-Nuo Wang^#, Zhuo-Hang Yu^#, Zeng-Rui Wu, Ze Wang, Shang Lou, Wei-Hua Li, Gui-Xia Liu, Ting Li*, Yu-Zheng Zhao, Yun Tang*. NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods. Acta Pharmacologica Sinica, 2024, 45(10), 2199-2211.  

4. Xie Li^#, Yinan Zhang^#, Lingyan Xu^#, Aoxue Wang^#, Yejun Zou^#, Ting Li^#, Li Huang^#, Weicai Chen^#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

5. Yajie Qian^#, Ting Li^#, Siyu Zhou, Xianjun Chen* and Yi Yang*. A single-component optogenetic Gal4-UAS system allows stringent control of gene expression in zebrafish and Drosophila. ACS Synthetic Biology, 2023, 12(3), 664-671.

6. Ting Li^#, Yejun Zou^#, Shuning Liu, Yi Yang, Zhuo Zhang*, Yuzheng Zhao*. Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors.Cell Regeneration, 2022, 11(1): 5.

7. Ting Li^#, Xianjun Chen^#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12(1): 615.

8. Xianjun Chen^#, Ting Li^#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44(6): 2677-2690.